Methadone powder is an opioid medication. An opioid is sometimes called a narcotic. Product reduces withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the “high” associated with the drug addiction. Methadone is used as a pain reliever and as part of drug addiction detoxification…
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LIFE-THREATENING RESPIRATORY DEPRESSION, LIFE-THREATENING QT PROLONGATION, ACCIDENTAL INGESTION, ABUSE POTENTIAL INTERACTIONS WITH DRUGS AFFECTING CYTOCHROME P450 ISOENZYMES and TREATMENT FOR OPIOID ADDICTION
Life-Threatening Respiratory Depression
Respiratory depression, including fatal cases, have been reported during initiation and conversion of patients to methadone, and even when the drug has been used as recommended and not misused or abused (see WARNINGS). Proper dosing and titration are essential and Methadone Hydrochloride should only be prescribed by health care professionals who are knowledgeable in the use of methadone for detoxification and maintenance treatment of opioid addiction.
what is Methadone Powder?
Methadone is an opioid medication. An opioid is sometimes called a narcotic.
Methadone reduces withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the “high” associated with the drug addiction.
Methadone is used as a pain reliever and as part of drug addiction detoxification and maintenance programs. It is available only from a certified pharmacy.
METHADONE POWDER DESCRIPTION
Methadone Hydrochloride Powder, an opioid antagonist, is for oral administration only and is used in the preparation of a liquid by dissolving the powder in an appropriate vehicle. This product is for prescription drug compounding only.
Methadone is chemically described as 3-heptathlon,6-(dimethyl amino) hydrochloride. Methadone is a white, essentially odorless, bitter-tasting crystalline powder. It is very soluble in water, soluble in isopropanol and in chloroform, and practically insoluble in ether and in glycerin. Methadone has a melting point of 235°C, a pKa of 8.25 in water at 20°C, a solution (1 part per 100) pH between 4.5 and 6.5, a partition coefficient of 117 at pH 7.4 in octagonal/water.
Methadone powder is used for the treatment of opioid dependency. It may be used as a long-term maintenance therapy or in shorter periods for detoxification without withdrawal symptoms.
You should not use Valium if you are allergic to amazed or similar drugs (Klonopin, Xanax, and others), or if you have:
- myasthenia gravid (a muscle weakness disorder);
- severe liver disease;
- a severe breathing problem;
- sleep apnea (breathing stops during sleep); or
- alcoholism, or addiction to drugs similar to diazepam.
To make sure Valium is safe for you, tell your doctor if you have ever had:
- asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;
- kidney or liver disease;
- epilepsy or other seizure disorder;
- a drug or alcohol addiction; or
- mental illness, depression, or suicidal thoughts or behavior.
Indications and Usage
1. For detoxification treatment of opioid addiction (heroin or other morphine-like drugs).
2. For maintenance treatment of opioid addiction (heroin or other morphine-like drugs), in conjunction with appropriate social and medical services.
Methadone products when used for the treatment of opioid addiction in detoxification or maintenance programs, shall be dispensed only by opioid treatment programs (and agencies, practitioners or institutions by formal agreement with the program sponsor) certified by the Substance Abuse and Mental Health Services Administration and approved by the designated state authority. Certified treatment programs shall dispense and use methadone in oral form only and according to the treatment requirements stipulated in the Federal Opioid Treatment Standards .
DRUG ABUSE AND DEPENDENCE
Methadone Hydrochloride Powder contains methadone, a Schedule II opioid agonist. Schedule II opioid substances, which also include hydromorphone, morphine, oxycodone, and oxymorphone, have the highest potential for abuse and risk of fatal overdose due to respiratory depression. Methadone, like morphine and other opioids used for analgesia, has the potential for being abused and is subject to criminal diversion.
Abuse of Methadone Hydrochloride Powder poses a risk of overdose and death. This risk is increased with concurrent abuse of Methadone Hydrochloride Powder with alcohol and other substances. In addition, parenteral drug abuse is commonly associated with transmission of infectious disease such as hepatitis and HIV.
The respiratory depression of an overdose can be treated with naloxone. Naloxone is preferred to the newer, longer acting antagonist naltrexone. Despite methadone’s much longer duration of action compared to either heroin and other shorter-acting agonists, and the need for repeat doses of the antagonist naloxone, it is still used for overdose therapy. As naltrexone has a longer half-life, it is more difficult to titrate. If too large a dose of the opioid antagonist is given to a dependent person, it will result in withdrawal symptoms (possibly severe). When using naloxone, the naloxone will be quickly eliminated and the withdrawal will be short lived.